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Kirschstein et al. discover that TGF receptor signaling in myofibroblasts blocks the differentiation of reticular fibroblasts associated with TLS formation in murine PDAC. Antagonizing TGFR1 allows LTBR-dependent T and B cell recruitment and increases tumor control. This work demonstrates barriers to TLS formation in PDAC applicable to other immunotherapy-resistant solid tumors.
Avat3r Large Animatable Gaussian Reconstruction Model for High-fidelity 3D Head Avatars Tobias Kirschstein 1,2, Javier Romero 2, Artem Sevastopolsky 1,2, Matthias Niener 1, Shunsuke Saito 2 1Technical University of Munich, 2Meta Reality Labs
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Semantic Scholar extracted view of "Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer" by Elijah Kirschstein et al.
Content Kirschstein et al. discover that TGF receptor signaling in myofibroblasts blocks the differentiation of reticular fibroblasts associated with TLS formation in murine PDAC. Antagonizing TGFR1 allows LTBR-dependent T and B cell recruitment and increases tumor control. This work demonstrates barriers to TLS formation in PDAC applicable to other immunotherapy-resistant solid tumors.
2012), the other based on minimum spanning trees (Kirschstein et al. 2012). Both methods can identify outliers (i.e., unbalanced designs) and reveal cluster structures in the data.
(2025) and Avat3r Kirschstein et al. (2025), FastAvatar handles variable-length obser-vation data with greater model flexibility and higher data utilization efficiency.
Radical cystectomy/Mainz S/P 1 TUR-bladder pT1 G3 and mpTis Pouch I. Kirschstein et al. BMC Urology (2015) 15:104. Page 4 of 9.
![Parameter values in case 1 and case 2 (Kirschstein et al. [37]; Ren [42 ... - Kirschstein Et Al](https://www.researchgate.net/publication/328032653/figure/tbl1/AS:677477173194753@1538534553984/Parameter-values-in-case-1-and-case-2-Kirschstein-et-al-37-Ren-42_Q320.jpg "Parameter values in case 1 and case 2 (Kirschstein et al. [37]; Ren [42 ...")
![Parameter values in case 1 and case 2 (Kirschstein et al. [37]; Ren [42 ...](https://www.researchgate.net/publication/328032653/figure/tbl1/AS:677477173194753@1538534553984/Parameter-values-in-case-1-and-case-2-Kirschstein-et-al-37-Ren-42.png "Parameter values in case 1 and case 2 (Kirschstein et al. [37]; Ren [42 ...")
